low activity against e coli atcc 35218  (ATCC)

Journal: Microorganisms

Article Title: Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

doi: 10.3390/microorganisms7020028

Figure Lengend Snippet: Minimum Inhibitory Concentration (MIC) values (µg/mL) of the tested compounds against selected microbial strains, assessed by broth microdilution method according to the Performance Standards for Antimicrobial Susceptibility Testing (CLSI Document M100-S2, 2013). Gentamicin and fluconazole were used as internal controls.

Article Snippet: On the contrary, all the derivatives ( 3 , 4 , and 8 ) showed low activity against E. coli ATCC 35218 biofilms, in some cases, also the derivatives reached remarkable percentages of biomass reduction.

Techniques: Concentration Assay

Journal: Microorganisms

Article Title: Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

doi: 10.3390/microorganisms7020028

Figure Lengend Snippet: Biofilm formation inhibition exerted by compounds 1 , 3 , 4 , and 8 . Each molecule was added at its relative MIC and 2× MIC (µg/mL) values during the biofilm formation of the different pathogens; the inhibition percentages were determined after spectrophotometer reader at 570 nm.

Article Snippet: On the contrary, all the derivatives ( 3 , 4 , and 8 ) showed low activity against E. coli ATCC 35218 biofilms, in some cases, also the derivatives reached remarkable percentages of biomass reduction.

Techniques: Inhibition, Spectrophotometry

Journal: Microorganisms

Article Title: Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

doi: 10.3390/microorganisms7020028

Figure Lengend Snippet: Assessment of viable cells harvested from biofilms of E. coli ATCC 35218, S. aureus ATCC 43387, K. pneumoniae 6/4 and C. albicans ATCC 10231 after 30 min of treatment with compounds 1 , 3 , 4 , and 8 at their relative MIC values. Data represent the mean ± SD of cfu/mL values obtained in three independent experiments performed in duplicate. Asterisks represent values statistically significant (* p < 0.05; ** p < 0.01; *** p < 0.001) as compared to the related controls.

Article Snippet: On the contrary, all the derivatives ( 3 , 4 , and 8 ) showed low activity against E. coli ATCC 35218 biofilms, in some cases, also the derivatives reached remarkable percentages of biomass reduction.

Techniques:

Journal: Microorganisms

Article Title: Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

doi: 10.3390/microorganisms7020028

Figure Lengend Snippet: Disaggregating efficacy of compounds 1 , 3 , 4 , and 8 at their relative MIC values, against biofilms of E. coli ATCC 35218, S. aureus ATCC 43387, K. pneumoniae 6/4 and C. albicans ATCC 10231, as assessed by spectrophotometer reader (OD 570nm ) after 30 min of contact. Data represent the mean ± SD obtained in three independent experiments performed in duplicate. Asterisks represent values statistically significant (* p < 0.05; ** p < 0.01) as compared to the related controls.

Article Snippet: On the contrary, all the derivatives ( 3 , 4 , and 8 ) showed low activity against E. coli ATCC 35218 biofilms, in some cases, also the derivatives reached remarkable percentages of biomass reduction.

Techniques: Spectrophotometry

Journal: Microorganisms

Article Title: Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

doi: 10.3390/microorganisms7020028

Figure Lengend Snippet: Percentages of biofilm eradication activity assessed for E. coli ATCC 35218, S. aureus ATCC 43387, K. pneumoniae 6/4 and C. albicans ATCC 10231 after 30 min of contact with compounds 1 , 3 , 4 , and 8 at their relative MIC (µg/mL) values. Percentages were determined after spectrophotometer reader (OD 570nm ).

Article Snippet: On the contrary, all the derivatives ( 3 , 4 , and 8 ) showed low activity against E. coli ATCC 35218 biofilms, in some cases, also the derivatives reached remarkable percentages of biomass reduction.

Techniques: Activity Assay, Spectrophotometry